Mpox caused by the monkeypox virus is spreading its footprints gradually. Cases have been reported from Pakistan which is adjacent to India. It is usually mild but can kill children, pregnant women and people with weakened immune system. There are two genetic groups. Clade I of Mpox is associated with more severe illness and higher fatality rates than clade II. The current upsurge of Mpox in parts of Africa along with the spread of a new sexually transmissible strain that poses a serious threat to the world. Mind you, when the 1st wave of Corona came to India, we were taking it for granted. And then the 2nd wave had come up with a barrage of casualties and human catastrophe. WHO warned of its highest level of alert over the outbreak of mpox in Africa. We must take precautionary measures and obey the guidelines issued by Government of India.